So, Nintendo at E3, huh? Well, here is what I want and that I'm 99% certain will happen.

1. The Legend of Zelda: Breath of the Four Swords (Expansion Pack)
C'mon, we got TWO expansions for BOTW? Zelda is the game that's all about three: The triforce, the spiritual stones, 3 days in Majora's Mask, and more. I want an EX: Four Swords. Add a new Korok Forest to the game that contains the Four Sword, that when equipped, allows you to play multiplayer local or online up to four players. If the sword breaks, everyone immediately dies.
I think that's all about BOTW that needs to be shown in E3.

2. Super Mario Land 3
I am an enjoyer of the GB Mario games and I feel like Nintendo would be losing a huuuge opportunity if they didn't make another GB Mario. C'mon, the GB enjoyers also need some love.

3. Metroid Other M 2
Why not?

4. Devil May Cry 6 (featuring Dante from the Devil May Cry series)
That would be one hell of a crossover